The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12

Genomics. 1990 Mar;6(3):413-8. doi: 10.1016/0888-7543(90)90470-f.

Abstract

Insulin-like growth factors (IGF) I and II are bound to high-affinity binding proteins in the blood circulation and other body fluids. These IGF-binding proteins are expressed at different concentrations in different tissues and are thought to regulate the activity of IGF I and II. Cloned cDNA for IGF-binding protein-1 (IGFBP1) has been used to verify the location of its gene to human chromosome 7 by Southern blotting to DNA from a human-mouse hybrid cell line. Further, by in situ hybridization the gene was regionally localized to 7p14-p12, and a Mendelian-inherited two-allele BglII restriction enzyme length polymorphism was identified, with the most frequent allele occurring in 53% of the chromosomes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrier Proteins / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 7* / ultrastructure
  • DNA / genetics
  • Genes
  • Humans
  • Insulin-Like Growth Factor Binding Proteins
  • Nucleic Acid Hybridization
  • Polymorphism, Restriction Fragment Length

Substances

  • Carrier Proteins
  • Insulin-Like Growth Factor Binding Proteins
  • DNA