Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo

Eur J Immunol. 2006 Sep;36(9):2367-75. doi: 10.1002/eji.200535722.


Dendritic cells (DC) can both initiate an immune response and dictate its character. Cytokines are critically involved in this process and, although interleukin (IL)-10 is known as a potent immunosuppressant, the impact of its release from DC remains unclear. Here, we transfer pathogen-conditioned murine DC in vivo and show that, while DC-derived IL-10 can act to limit Th1 development, it is not required for Th2 induction. In both Th2 and Th1 settings, however, IL-10 from cells other than the initiating DC dominates the regulation of the emerging effector cell populations. Surprisingly, the critical source of IL-10 in this process is neither T nor B cells. These data illustrate the distinct actions of IL-10 during differently polarised, pathogen-focussed, DC-driven immune responses in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Antigens, Bacterial / immunology
  • Antigens, Helminth / immunology
  • B-Lymphocytes / immunology
  • Dendritic Cells / immunology*
  • Interleukin-10 / deficiency
  • Interleukin-10 / immunology*
  • Lymphocyte Activation*
  • Mice
  • Th1 Cells / immunology*
  • Th2 Cells / immunology*


  • Antigens, Bacterial
  • Antigens, Helminth
  • Interleukin-10