Role of dendritic cells in Sjögren's syndrome

Scand J Immunol. 2006 Sep;64(3):219-26. doi: 10.1111/j.1365-3083.2006.01811.x.


Sjögren's syndrome (SS) is a chronic inflammatory and lymphoproliferative autoimmune disease of unknown aetiology. It is characterised by progressive mononuclear cell infiltration of the salivary and lacrimal glands and a decreased glandular secretion, resulting in dryness of the mouth and eyes (xerostomia and keratoconjunctivitis sicca, respectively). Dendritic cells (DC) are considered to be the most potent antigen-presenting cells. Because of their central role in initiating an immune response while maintaining tolerance, impaired function of these cells might lead to the break of peripheral tolerance and initiation of immune responses to self-antigens. This review will focus on the possible role of DC in SS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoimmunity
  • Biomarkers / analysis
  • Chemokines / physiology*
  • Cytokines / physiology*
  • Dendritic Cells / immunology
  • Dendritic Cells / physiology*
  • Humans
  • Immune Tolerance
  • Mice
  • Models, Immunological
  • Receptors, Complement 3b / analysis
  • Receptors, Complement 3d / analysis
  • Sjogren's Syndrome / immunology*


  • Biomarkers
  • Chemokines
  • Cytokines
  • Receptors, Complement 3b
  • Receptors, Complement 3d