The control of histone lysine methylation in epigenetic regulation

Biochimie. 2007 Jan;89(1):1-20. doi: 10.1016/j.biochi.2006.07.009. Epub 2006 Aug 4.


Histone lysine methylation plays a fundamental role in chromatin organization and function. This epigenetic mark is involved in many biological processes such as heterochromatin formation, chromosome X inactivation, genomic imprinting and transcriptional regulation. Here, we review recent advances in how histone lysine methylation participates in these biological events, and the enzymes that control histone lysine methylation and demethylation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromatin Assembly and Disassembly
  • Epigenesis, Genetic*
  • Histones / metabolism*
  • Humans
  • Lysine / metabolism*
  • Methylation
  • Methyltransferases / chemistry
  • Methyltransferases / physiology*
  • Models, Genetic
  • Transcription, Genetic


  • Histones
  • Methyltransferases
  • Lysine