How many signals impinge on GLUT4 activation by insulin?

Cell Signal. 2007 Jan;19(1):1-7. doi: 10.1016/j.cellsig.2006.05.018. Epub 2006 Jun 2.


GLUT4 is the main glucose transporter activated by insulin in skeletal muscle cells and adipocytes. GLUT4 storage vesicles (GSVs) traffic in endocytic and exocytic compartments. In the basal state, GLUT4 compartments are preferentially sequestered in perinuclear deposits wherein stimuli including insulin and non-insulin factors can increase GLUT4 vesicle formation, its exocytosis, and fusion to plasma membrane. In addition to well-established effectors of insulin signaling pathway, such as PKCzeta and Akt, the cytoskeletal network is implicated in GLUT4 translocation. This review will discuss the mechanisms and activation of GLUT4 trafficking and incorporating to PM from three aspects: known molecules of the insulin signaling pathway; Rho and Rab family proteins and cytoskeletal molecules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Cytoskeleton / metabolism
  • Endocytosis
  • Exocytosis
  • Glucose Transporter Type 4 / physiology*
  • Humans
  • Insulin / physiology*
  • Phosphatidylinositols / metabolism
  • Phosphoprotein Phosphatases / physiology
  • Protein Transport
  • Signal Transduction*
  • rab GTP-Binding Proteins / physiology
  • rho GTP-Binding Proteins / physiology


  • Glucose Transporter Type 4
  • Insulin
  • Phosphatidylinositols
  • Phosphoprotein Phosphatases
  • rab GTP-Binding Proteins
  • rho GTP-Binding Proteins