Detection of hepatic metastasis: manganese- and ferucarbotran-enhanced MR imaging

Eur J Radiol. 2006 Oct;60(1):84-90. doi: 10.1016/j.ejrad.2006.06.016. Epub 2006 Aug 21.


Purpose: To compare the mangafodipir trisodium (MnDPDP)-enhanced and ferucarbotran-enhanced magnetic resonance imaging (MRI) for the detection of hepatic metastases.

Material and methods: Twenty patients with known hepatic metastasis underwent MR imaging using mangafodipir trisodium and ferucarbotran in at least 1-day intervals. Thirty-eight metastases were confirmed either histologically or clinically. Two radiologists independently reviewed the MnDPDP-enhanced and ferucarbotran-enhanced sets in a random order. The sensitivity and accuracy of lesion detection and the ability to distinguish a benign lesion from a malignant lesion were compared by the areas (Az) under the receiver operating characteristic (ROC) curve. The lesion-liver contrast-to-noise ratios (CNR) were compared by paired t-test.

Results: The overall accuracy for detecting metastases was not significantly different between the MnDPDP set (Az=0.912 and 0.913 for reader 1 and 2, respectively) and the SPIO set (Az=0.920 and 0.950). The CNR at the MnDPDP-enhanced images and the SPIO-enhanced images were not significantly different (P=0.146).

Conclusion: Both MnDPDP- and ferucarbotran-enhanced MRI have a comparable accuracy in detecting hepatic metastasis.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Contrast Media
  • Dextrans
  • Edetic Acid / analogs & derivatives*
  • Female
  • Ferrosoferric Oxide
  • Humans
  • Image Enhancement / methods*
  • Iron*
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / secondary*
  • Magnetic Resonance Imaging / methods*
  • Magnetite Nanoparticles
  • Male
  • Middle Aged
  • Oxides*
  • Pyridoxal Phosphate / analogs & derivatives*
  • Reproducibility of Results
  • Sensitivity and Specificity


  • Contrast Media
  • Dextrans
  • Magnetite Nanoparticles
  • Oxides
  • Pyridoxal Phosphate
  • Edetic Acid
  • Iron
  • ferumoxides
  • N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
  • Ferrosoferric Oxide