Dendritic cell and macrophage subsets in the handling of dying cells

Immunobiology. 2006;211(6-8):567-75. doi: 10.1016/j.imbio.2006.05.023. Epub 2006 Jul 5.


Dendritic cells and macrophages are major components of the phagocyte system and are professional antigen presenting cells. In the current review, we discuss the differential contribution of dendritic cell and macrophage subsets in the clearance of dying cells and the consequences of these processes. We hypothesize that under steady-state conditions, the clearance of apoptotic cells is mostly confined to a specialized subset of phagocytes with anti-inflammatory properties.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Dendritic Cells / physiology*
  • Humans
  • Macrophages / physiology*
  • Necrosis / pathology
  • Phagocytosis / physiology