Antihyperglycemic activity of Tarralin, an ethanolic extract of Artemisia dracunculus L

Phytomedicine. 2006 Sep;13(8):550-7. doi: 10.1016/j.phymed.2005.09.007. Epub 2005 Nov 2.


The studies reported here were undertaken to examine the antihyperglycemic activity of an ethanolic extract of Artemisia dracunculus L., called Tarralin in diabetic and non-diabetic animals. In genetically diabetic KK-A(gamma) mice, Tarralin treatment by gavage (500 mg/kg body wt./day for 7 days) lowered elevated blood glucose levels by 24% from 479+/-25 to 352+/-16 mg/dl relative to control animals. In comparison, treatment with the known antidiabetic drugs, troglitazone (30 mg/kg body wt./day) and metformin (300 mg/kg body wt./day), decreased blood glucose concentrations by 28% and 41%, respectively. Blood insulin concentrations were reduced in the KK-A(gamma) mice by 33% with Tarralin, 48% with troglitazone and 52% with metformin. In (STZ)-induced diabetic mice, Tarralin treatment, (500 mg/kg body wt./day for 7 days), also significantly lowered blood glucose concentrations, by 20%, from 429+/-41 to 376+/-58 mg/dl relative to control. As a possible mechanism, Tarralin was shown to significantly decrease phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression by 28% in STZ-induced diabetic rats. In non-diabetic animals, treatment with Tarralin did not significantly alter PEPCK expression, blood glucose or insulin concentrations. The extract was also shown to increase the binding of glucagon-like peptide (GLP-1) to its receptor in vitro. These results indicate that Tarralin has antihyperglycemic activity and a potential role in the management of diabetic states.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Artemisia / chemistry*
  • Blood Glucose / drug effects*
  • Chromatography, High Pressure Liquid
  • Diabetes Mellitus, Experimental / drug therapy*
  • Gene Expression / drug effects
  • Glucagon-Like Peptide 1 / antagonists & inhibitors
  • Glutathione Peroxidase / drug effects
  • Hypoglycemic Agents / analysis
  • Hypoglycemic Agents / pharmacology*
  • Liver / enzymology
  • Male
  • Mass Spectrometry
  • Mice
  • Mice, Inbred ICR
  • Plant Extracts / analysis
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Sprague-Dawley


  • Blood Glucose
  • Hypoglycemic Agents
  • Plant Extracts
  • phosphoenolpyruvate carboxykinase ferroactivator protein, rat
  • Glucagon-Like Peptide 1
  • Glutathione Peroxidase