Fatherhood affects dendritic spines and vasopressin V1a receptors in the primate prefrontal cortex

Nat Neurosci. 2006 Sep;9(9):1094-5. doi: 10.1038/nn1753. Epub 2006 Aug 20.

Abstract

Like human fathers, male marmosets help raise their young, yet the ways in which fatherhood influences the brain remain largely unknown. We show that first-time and experienced marmoset fathers have enhanced density of dendritic spines on pyramidal neurons in prefrontal cortex as compared to non-fathers. In parallel, the abundance of vasopressin V1a receptors and the proportion of V1a receptor-labeled dendritic spines increase.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Callithrix
  • Dendritic Spines / metabolism*
  • Male
  • Prefrontal Cortex / cytology
  • Prefrontal Cortex / metabolism*
  • Pyramidal Cells / cytology
  • Pyramidal Cells / metabolism
  • Receptors, Vasopressin / metabolism*
  • Vasopressins / metabolism

Substances

  • Receptors, Vasopressin
  • Vasopressins