Macrocyclization by Ring-Closing Metathesis in the Total Synthesis of Natural Products: Reaction Conditions and Limitations

Angew Chem Int Ed Engl. 2006 Sep 18;45(37):6086-101. doi: 10.1002/anie.200600641.


The construction of macrocycles by ring-closing metathesis (RCM) is often used as the key step in the synthesis of natural products containing large rings. This reaction is attractive because of its high functional group compatibility and the possibility for further transformations. The finding of suitable reaction conditions is critical for the success of the synthesis. In this Minireview we summarize the efforts of many research groups to develop efficient RCM reactions on their way towards the total synthesis of natural macrocyclic products. Their findings should help in future synthesis to reduce the time-consuming phase of the optimization of the reaction conditions.

Publication types

  • Portrait
  • Review

MeSH terms

  • Biological Products / chemical synthesis*
  • Biological Products / chemistry
  • Catalysis
  • Cyclization
  • Macrocyclic Compounds / chemical synthesis*
  • Macrocyclic Compounds / chemistry


  • Biological Products
  • Macrocyclic Compounds