Determination of suspected allergens in non-volatile matrices using PTV injection with automated liner exchange and GC-MS

J Sep Sci. 2006 Jul;29(11):1587-94. doi: 10.1002/jssc.200500410.

Abstract

A method is described for the analysis of suspected volatile allergens in products containing high molecular weight or non-volatile compounds such as plant extracts, solid and liquid detergents, shampoos, etc. The method is based on dissolution/extraction of the sample followed by direct injection in a programmed temperature vaporizing inlet, the liner of which contains PDMS foam to retain the high molecular weight non-volatile material. The liner is automatically replaced after each injection, by an automated liner exchange device. Analysis is done by GC-MS operated in the retention-time locked mode. The figures of merit are illustrated with the analysis of some real samples.

MeSH terms

  • Allergens / analysis*
  • Gas Chromatography-Mass Spectrometry / methods*
  • Gas Chromatography-Mass Spectrometry / standards
  • Reference Standards
  • Temperature
  • Volatilization

Substances

  • Allergens