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doi: 10.1016/j.cell.2006.08.005.
ZOning out tight junctions
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- PMID: 16923383
- DOI: 10.1016/j.cell.2006.08.005
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ZOning out tight junctions
Cell.
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Abstract
The tight junction is an intricate seal between adjoining epithelial cells that also separates the apical and basolateral membranes within these cells. A paper in this issue of Cell by Umeda et al. (2006) demonstrates that loss of the ZO scaffolding proteins prevents the formation of tight junctions but surprisingly does not perturb apico-basal polarity.
Comment on
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ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.Cell. 2006 Aug 25;126(4):741-54. doi: 10.1016/j.cell.2006.06.043. Cell. 2006. PMID: 16923393
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