A transcriptional logic for nuclear reprogramming

Cell. 2006 Aug 25;126(4):652-5. doi: 10.1016/j.cell.2006.08.009.


Limitations on a differentiated cell's pluripotency can be erased by nuclear transfer or by fusion with embryonic stem cells, but attempts to recapitulate this process of nuclear reprogramming by molecular means have failed. In this issue of Cell, Takahashi and Yamanaka (2006) take a rational approach to identifying a suite of embryonic transcription factors whose overexpression restores pluripotency to adult somatic cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • Embryo, Mammalian / cytology
  • Hybrid Cells* / cytology
  • Hybrid Cells* / physiology
  • Mice
  • Pluripotent Stem Cells* / cytology
  • Pluripotent Stem Cells* / physiology
  • Transcription Factors / metabolism
  • Transcription, Genetic*
  • Transgenes


  • Transcription Factors