EBV-associated synovial lymphoma in a chronically inflamed joint in rheumatoid arthritis receiving prolonged methotrexate treatment

Haematologica. 2006 Aug;91(8 Suppl):ECR31.


A patient with longstanding rheumatoid arthritis (RA) developed swelling in a chronically inflamed knee joint while receiving prolonged methotrexate treatment. Magnetic resonance imaging and positron-emission tomography showed soft tissue swelling with intense tracer uptake. Biopsy confirmed high-grade B-cell lymphoma. He developed complete remission with rituximab plus CEOP. The role of chronic inflammation and methotrexate in the pathogenesis of lymphoma in RA was discussed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antirheumatic Agents / adverse effects*
  • Antirheumatic Agents / therapeutic use
  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / drug therapy
  • Epstein-Barr Virus Infections / chemically induced*
  • Herpesvirus 4, Human
  • Humans
  • Knee Joint / pathology
  • Lymphoma, B-Cell / chemically induced*
  • Male
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use


  • Antirheumatic Agents
  • Methotrexate