This descriptive study examined relationships between depression, health-promoting lifestyles, and physical illnesses in a sample of persons living in the community who self-reported being diagnosed with mental illnesses. Variables of age, gender, and participation in psychiatric rehabilitation services were investigated to determine significant relationships to depression and lifestyles. Fifty adults completed a demographic survey, the CES-Depression scale, and the Health-Promoting Lifestyle Profile II. The findings emphasize the importance of psychiatric nurses assessing health-promoting lifestyles comprehensively in persons with serious mental illnesses and facilitating changes to improve both physical and mental health.