Specificity in reactive oxidant signaling: think globally, act locally

J Cell Biol. 2006 Aug 28;174(5):615-23. doi: 10.1083/jcb.200605036. Epub 2006 Aug 21.


Although reactive oxidants have long been stigmatized as unwanted metabolic byproducts, the expression of oxidases specifically functioning to produce these same molecules in a regulated fashion is surprisingly pervasive throughout metazoan and plant evolution. Although the involvement of oxidants in many signaling pathways is well documented, the cellular strategies for conferring pathway specificity to such reactive molecules have remained more recondite. Recent studies now suggest that cells may spatially restrict oxidant production to allow microdomain-specific signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium Signaling
  • Cytosol / metabolism*
  • Evolution, Molecular
  • Homeostasis
  • Humans
  • Mitochondria / metabolism*
  • NADPH Oxidases / genetics
  • NADPH Oxidases / metabolism
  • Oxidative Stress*
  • Reactive Oxygen Species / metabolism*
  • Signal Transduction*
  • Tyrosine / metabolism
  • rac1 GTP-Binding Protein / metabolism


  • Reactive Oxygen Species
  • Tyrosine
  • NADPH Oxidases
  • neutrophil cytosolic factor 1
  • rac1 GTP-Binding Protein