Radioembolization with 90Yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. Part 1: Technical and methodologic considerations

J Vasc Interv Radiol. 2006 Aug;17(8):1251-78. doi: 10.1097/01.RVI.0000233785.75257.9A.


Microsphere and particle technology represent the next-generation agents that have formed the basis of interventional oncology, an evolving subspecialty of interventional radiology. One of these platforms, yttrium-90 microspheres, is rapidly being adopted in the medical community as an adjunctive therapeutic tool in the management of primary and secondary liver malignancies. Given the complexity of the treatment algorithm of patients who may be candidates for this therapy and the need for clinical guidance, a comprehensive review of the methodologic and technical considerations was undertaken. This experience is based on more than 900 (90)Y infusions performed over a 5-year period.

Publication types

  • Review

MeSH terms

  • Angiography
  • Brachytherapy* / methods
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / physiopathology
  • Carcinoma, Hepatocellular / radiotherapy*
  • Carcinoma, Hepatocellular / secondary
  • Disease Management
  • Embolization, Therapeutic* / methods
  • Humans
  • Liver Neoplasms / pathology
  • Liver Neoplasms / physiopathology
  • Liver Neoplasms / radiotherapy*
  • Liver Neoplasms / secondary
  • Mesentery / blood supply
  • Mesentery / diagnostic imaging
  • Microspheres
  • Patient Care Team
  • Patient Selection
  • Practice Guidelines as Topic
  • Radiology, Interventional
  • Radiopharmaceuticals / therapeutic use
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted*
  • Splanchnic Circulation
  • Tomography, X-Ray Computed
  • Yttrium Radioisotopes / therapeutic use*


  • Radiopharmaceuticals
  • Yttrium Radioisotopes