Interactions between cytokines and alpha 2-macroglobulin

Immunol Today. 1990 May;11(5):163-6. doi: 10.1016/0167-5699(90)90067-j.


Cytokines are often thought of as short range, short half-life molecules. This view may now be challenged by recent findings that indicate that alpha 2-macroglobulin and antibodies to cytokines may alter cytokine kinetics in vivo. alpha 2-Macroglobulin, one of the major proteins in serum, can bind a wide range of physiologically important molecules. As Keith James reviews here, the interaction between alpha 2-macroglobulin and a number of cytokines has recently come under scrutiny, revealing a new and potentially important mechanism for the modulation of cytokine activity, while in the following paper a modulatory role for anti-cytokine antibodies is considered.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Factors / blood*
  • Biological Factors / pharmacokinetics
  • Cytokines
  • Humans
  • Immunity / physiology
  • Immunoassay
  • Protein Binding / physiology
  • alpha-Macroglobulins / metabolism*
  • alpha-Macroglobulins / physiology


  • Biological Factors
  • Cytokines
  • alpha-Macroglobulins