Changes in adrenergic and peptidergic nerves in the submucous plexus of streptozocin-diabetic rat ileum

Gastroenterology. 1990 Jun;98(6):1427-36. doi: 10.1016/0016-5085(90)91072-e.


The effect of streptozocin diabetes on the distribution of adrenergic and peptidergic nerves in the submucous plexus of rat ileum was investigated and compared with the changes in the myenteric plexus of the same region of ileum. There was an increase in the intensity of immunoreactivity in vasoactive intestinal polypeptide- and neuropeptide Y-like immunoreactive nerve fibers and neurons and a decrease in calcitonin gene-related peptide-like immunoreactivity but no change in substance P- and dopamine beta-hydroxylase-like immunoreactivity in the nerve fibers and neurons of the submucous plexus of both 8- and 16-wk streptozocin-diabetic rat ileum. However, in the myenteric plexus of the diabetic rat ileum, there was enlargement of varicosities and an increase followed by a slight decrease in the intensity of immunoreactivity of vasoactive intestinal polypeptide- and dopamine beta-hydroxylase-like immunoreactive nerve fibers and neurons, increased substance P-like immunoreactivity in diabetes at 16 wk, and an initial decrease (at 8 wk) followed by a recovery of calcitonin gene-related peptide-like immunoreactivity at 16 wk, but no change in neuropeptide Y-like immunoreactivity. The markedly different changes in peptidergic and adrenergic nerves between the two enteric plexuses show that diabetic neuropathy induced by streptozocin is not selective and involves factors other than neurotransmitter types.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic Fibers / pathology*
  • Animals
  • Calcitonin Gene-Related Peptide / analysis
  • Diabetes Mellitus, Experimental / pathology*
  • Dopamine beta-Hydroxylase / analysis
  • Ileum / innervation*
  • Immunohistochemistry
  • Male
  • Myenteric Plexus / pathology*
  • Nerve Fibers / ultrastructure
  • Neurons / ultrastructure
  • Neuropeptide Y / analysis
  • Rats
  • Rats, Inbred Strains
  • Streptozocin
  • Submucous Plexus / pathology*
  • Substance P / analysis
  • Vasoactive Intestinal Peptide / analysis


  • Neuropeptide Y
  • Substance P
  • Vasoactive Intestinal Peptide
  • Streptozocin
  • Dopamine beta-Hydroxylase
  • Calcitonin Gene-Related Peptide