Anaplastic secretory meningioma: a case report

Pathologica. 2006 Apr;98(2):153-5.


Secretory meningiomas are rare histological subtypes of meningiomas with benign biological behaviour. In this study, the authors describe the first case of secretory meningioma with many mitotic figures and brain invasion, and discuss the clinicopathologic features including immunohistochemical staining profile and ultrastructural appearance of this tumour. A case of a 54-year-old man diagnosed with an intracranial tumour located in the left frontal lobe is presented. On pre-contrast CT scans, the tumour was hypodense and the contrast enhancement was marked in the pseudo membrane. The tumour was partially removed. The histological diagnosis was secretory meningioma with many mitotic figures, a high MIB-1 labeling index and a brain invasion.

Publication types

  • Case Reports

MeSH terms

  • Carcinoembryonic Antigen / analysis
  • Combined Modality Therapy
  • Cranial Irradiation
  • Frontal Lobe / pathology*
  • Frontal Lobe / surgery
  • Humans
  • Keratins / analysis
  • Ki-67 Antigen / analysis
  • Male
  • Meningeal Neoplasms / chemistry
  • Meningeal Neoplasms / pathology*
  • Meningeal Neoplasms / radiotherapy
  • Meningeal Neoplasms / surgery
  • Meningioma / chemistry
  • Meningioma / pathology*
  • Meningioma / radiotherapy
  • Meningioma / surgery
  • Middle Aged
  • Mitotic Index
  • Mucin-1 / analysis
  • Neoplasm Invasiveness
  • Neoplasm Proteins / analysis
  • Neoplasm Recurrence, Local / radiotherapy
  • Radiotherapy, Adjuvant


  • Carcinoembryonic Antigen
  • Ki-67 Antigen
  • Mucin-1
  • Neoplasm Proteins
  • Keratins