Leukopenia and neutropenia induced by quetiapine

Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):292-4. doi: 10.1016/j.pnpbp.2006.07.003. Epub 2006 Aug 22.


Leukopenia and neutropenia are recognised as side effects of antipsychotic medication, notably clozapine. A case is presented in which a female Caucasian patient who had previously developed these side effects with clozapine also developed them with quetiapine in conjunction with semisodium valproate. There was no such reaction to zuclopenthixol, sulpiride, olanzapine and aripiprazole. It is concluded that caution should be exercised when treating with quetiapine especially where there has been neutropenia with a previous antipsychotic agent.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antimanic Agents / adverse effects
  • Antipsychotic Agents / adverse effects*
  • Dibenzothiazepines / adverse effects*
  • Drug Resistance
  • Female
  • Humans
  • Leukopenia / chemically induced*
  • Neutropenia / chemically induced*
  • Quetiapine Fumarate
  • Recurrence
  • Schizophrenia / drug therapy
  • Valproic Acid / adverse effects


  • Antimanic Agents
  • Antipsychotic Agents
  • Dibenzothiazepines
  • Quetiapine Fumarate
  • Valproic Acid