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Comparative Study
. 2006 Sep 18;17(13):1427-31.
doi: 10.1097/01.wnr.0000233099.97784.45.

Age-related Changes in Prefrontal White Matter Volume Across Adolescence

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Free PMC article
Comparative Study

Age-related Changes in Prefrontal White Matter Volume Across Adolescence

Bonnie J Nagel et al. Neuroreport. .
Free PMC article

Abstract

Past research has suggested that white matter volume increases from childhood to adulthood; however, during adolescence, there is somewhat limited data to support this finding. In the present study, 65 typically developing adolescents underwent structural magnetic resonance imaging. Using magnetic resonance imaging, prefrontal white matter volumes were examined in relation to adolescent age and sex. Surprisingly, results suggested that prefrontal white matter volume decreased during late adolescence, particularly among the female sex. These findings are inconsistent with past research and suggest that perhaps some developmental processes in late adolescence are not yet fully explained. Possible methodological contributions and implications for the current findings are discussed.

Figures

Fig. 1
Fig. 1
Representative segmentation of prefrontal white matter (denoted in black) using functional magnetic resonance imaging of the brain’s automated segmentation tool [16]. Includes all cortical white matter anterior to the anterior commissure.
Fig. 2
Fig. 2
Graphical representation of best fit models for the relationship between age and prefrontal white matter volume [expressed as a ratio to overall intracranial volume (ICV)] within the whole sample (n=65, r2=17%, P < 0.01), males only (n=34, r2=3%, NS), and females only (n=31, r2=37%, P < 0.01).

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