Mechanisms of disease: The pathogenesis of pituitary tumors

Nat Clin Pract Endocrinol Metab. 2006 Apr;2(4):220-30. doi: 10.1038/ncpendmet0159.


Pituitary tumors exhibit a spectrum of biology, with variable growth and hormonal behaviors. They therefore provide an opportunity to examine pathogenetic mechanisms that underlie the neoplastic process. These include alterations in hormone regulation, growth-factor stimulation, cell-cycle control and cell-stromal interactions that result from genetic mutations or epigenetic disruption of gene expression. Mouse models have validated the roles of these alterations, which can be targets for the development of therapies that can manage these lesions. These therapies are increasingly recognized as critical for quality of life.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenoma / classification
  • Adenoma / pathology
  • Adenoma / physiopathology
  • Animals
  • Cell Cycle
  • Disease Models, Animal
  • Growth Substances / physiology
  • Humans
  • Mice
  • Pituitary Neoplasms / classification
  • Pituitary Neoplasms / pathology
  • Pituitary Neoplasms / physiopathology*


  • Growth Substances