Fatal hyponatremia in a young woman after ecstasy ingestion

Nat Clin Pract Nephrol. 2006 May;2(5):283-8, quiz 289. doi: 10.1038/ncpneph0167.


Background: A 20-year old, otherwise healthy, female college student presented in an unresponsive state with respiratory distress after ingesting ecstasy (3,4-methylenedioxymethamphetamine). She had initial plasma sodium concentration of 117 mmol/l.

Investigations: Physical examination, blood chemistry panel, urinary osmolality and electrolytes, arterial blood gas, chest X-ray, and CT scan of the brain.

Diagnosis: Hyponatremia associated with noncardiogenic pulmonary edema and cerebral edema.

Management: Administration of a total of 6.8 l of isotonic saline and 0.245 l of 3% hypertonic saline with sporadic administration of intravenous furosemide. The patient died approximately 12 h after admission.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Fatal Outcome
  • Female
  • Hallucinogens / poisoning*
  • Humans
  • Hyponatremia / chemically induced*
  • N-Methyl-3,4-methylenedioxyamphetamine / poisoning*


  • Hallucinogens
  • N-Methyl-3,4-methylenedioxyamphetamine