Disodium pamidronate for treating severe hypercalcemia in a hemodialysis patient

Nat Clin Pract Nephrol. 2006 Aug;2(8):459-63; quiz 464. doi: 10.1038/ncpneph0248.


Background: A 48-year-old man with a recent diagnosis of multiple myeloma and rapidly progressive oliguric end-stage renal disease requiring hemodialysis, presented with a serum calcium concentration of 3.4 mmol/l (13.6 mg/dl).

Investigations: Serum laboratory analysis, electroencephalogram, MRI of the brain and bone marrow, and kidney biopsies.

Diagnosis: Hypercalcemia secondary to multiple myeloma.

Management: Short-term intravenous disodium pamidronate therapy (30 mg daily) and daily monitoring of serum calcium concentration.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Diphosphonates / therapeutic use*
  • Humans
  • Hypercalcemia / drug therapy*
  • Hypercalcemia / etiology
  • Kidney Failure, Chronic / etiology*
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Multiple Myeloma / complications*
  • Multiple Myeloma / drug therapy
  • Pamidronate
  • Renal Dialysis*


  • Antineoplastic Agents
  • Diphosphonates
  • Pamidronate