Lymphocytic mastopathy. An autoimmune disease of the breast?

Am J Clin Pathol. 1990 Jun;93(6):725-30. doi: 10.1093/ajcp/93.6.725.


Eight cases are reported of an unusual breast lesion consisting of dense intralobular, perilobular, and perivascular lymphocytic infiltrates associated with lobular atrophy and sclerosis. Immunologic studies on paraffin-embedded tissue (seven cases) and frozen tissue (two cases) demonstrated a predominance of B-cells and expression of HLA-DR antigen in involved lobular epithelium. The immunologic features of this lesion are reminiscent of lymphoepithelial lesions of salivary glands and other sites. A possible autoimmune pathogenesis is suggested.

MeSH terms

  • Adult
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology*
  • Breast Diseases / diagnosis
  • Breast Diseases / immunology
  • Breast Diseases / pathology*
  • Epitopes / analysis
  • Female
  • Humans
  • Lymphocytes / immunology
  • Lymphocytes / pathology*
  • Mastitis / diagnosis
  • Mastitis / immunology
  • Mastitis / pathology*
  • Middle Aged


  • Epitopes