IRFs: Master Regulators of Signalling by Toll-like Receptors and Cytosolic Pattern-Recognition Receptors

Nat Rev Immunol. 2006 Sep;6(9):644-58. doi: 10.1038/nri1900.

Abstract

The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown to have functionally diverse roles in the regulation of the immune system. Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll-like receptors and other pattern-recognition receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytosol / immunology*
  • Cytosol / metabolism
  • Disease
  • Humans
  • Interferon Regulatory Factors / immunology*
  • Interferon Regulatory Factors / metabolism
  • Receptors, Pattern Recognition / immunology*
  • Receptors, Pattern Recognition / metabolism
  • Signal Transduction / immunology*
  • Toll-Like Receptors / immunology*
  • Toll-Like Receptors / metabolism

Substances

  • Interferon Regulatory Factors
  • Receptors, Pattern Recognition
  • Toll-Like Receptors