Tissue-tropic effector T cells: generation and targeting opportunities

Nat Rev Immunol. 2006 Sep;6(9):682-92. doi: 10.1038/nri1869.


The localization of effector T cells to extralymphoid tissues is crucial for the generation of an effective immune response, but it also underlies many autoimmune and inflammatory disorders. Recent studies have highlighted a central role for draining lymph nodes and environmentally imprinted dendritic cells in the generation of tissue-tropic effector T cells. Here, I outline our current understanding of the mechanisms that regulate the generation and localization of tissue-tropic effector T cells, and the potential ways in which these pathways can be exploited for immunotherapeutic purposes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cell Lineage
  • Cell Movement*
  • Dendritic Cells / immunology
  • Humans
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / immunology
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / immunology*