Studies of HLA associations in male and female patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)

J Neuroimmunol. 2006 Nov;180(1-2):172-7. doi: 10.1016/j.jneuroim.2006.07.017. Epub 2006 Aug 28.


HLA associations are found to differ with the gender of the patient in some autoimmune diseases. Here we have investigated whether there are gender-related HLA associations in Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), both of which occur more frequently in male patients than in females. In GBS, no particular HLA associations were noted, except for a slight negative association in both males and females for carriage of HLA-DR5. In CIDP, the gene frequency and the frequency of individuals positive for HLA-DR2 were greater in female patients than female controls, although this was statistically significant only for the gene frequency. Furthermore more female CIDP patients were homozygous for DR2, than male CIDP patients, or male or female controls and patients with GBS. This suggests that sex-related factors may interact with the risk associated with carriage of HLA-DR2 for development of CIDP.

MeSH terms

  • DNA Mutational Analysis
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics
  • Genetic Testing
  • Guillain-Barre Syndrome / genetics*
  • Guillain-Barre Syndrome / immunology
  • Guillain-Barre Syndrome / physiopathology
  • HLA Antigens / genetics*
  • HLA Antigens / immunology
  • HLA-DR2 Antigen / genetics
  • HLA-DR2 Antigen / immunology
  • HLA-DR5 Antigen / genetics
  • HLA-DR5 Antigen / immunology
  • Heterozygote
  • Humans
  • Male
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / genetics*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / immunology
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / physiopathology
  • Sex Characteristics*
  • Sex Factors


  • HLA Antigens
  • HLA-DR2 Antigen
  • HLA-DR5 Antigen