Transcription factors of beta-cell differentiation and maturation in isolated human islets: effects of high glucose, high free fatty acids and type 2 diabetes

Nutr Metab Cardiovasc Dis. 2006 Sep;16(6):e7-8. doi: 10.1016/j.numecd.2005.07.012. Epub 2006 Mar 31.
No abstract available

Publication types

  • Letter

MeSH terms

  • Aged
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Diabetes Mellitus, Type 2 / metabolism*
  • Fatty Acids, Nonesterified / pharmacology*
  • Female
  • Glucose / pharmacology*
  • Hepatocyte Nuclear Factor 3-alpha / genetics
  • Homeodomain Proteins / genetics
  • Humans
  • Islets of Langerhans / physiology*
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / genetics
  • Paired Box Transcription Factors / genetics
  • RNA, Messenger / analysis
  • Transcription Factors / genetics*

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • FOXA1 protein, human
  • Fatty Acids, Nonesterified
  • Hepatocyte Nuclear Factor 3-alpha
  • Homeodomain Proteins
  • NEUROD1 protein, human
  • NEUROG3 protein, human
  • NKX6-1 protein, human
  • Nerve Tissue Proteins
  • PAX4 protein, human
  • Paired Box Transcription Factors
  • RNA, Messenger
  • Transcription Factors
  • Glucose