Effects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice

Circ J. 2006 Sep;70(9):1216-9. doi: 10.1253/circj.70.1216.


Background: Recent evidence suggests that oxidative stress may play a role in the development of atherosclerosis. MCI-186 (3-methyl-1-phenyl-1-phyrazolin-5-one, edaravone) is a novel free radical scavenger, but it remains unclear whether free radical scavengers would be effective for the prevention of the disease.

Methods and results: Experimental atherosclerosis was induced in apolipoprotein E-deficient mice fed a high-fat diet containing 0.3% cholesterol. Mice were treated with an intraperitoneal injection of either MCI-186 1 mg/kg per day or MCI-186 10 mg/kg per day on alternate days over 4 weeks. Fatty streak lesion was suppressed by MCI-186 10 mg/kg per day administration, but not by mg/kg per day. Immunohistochemical analysis showed that macrophage and CD4+ T-cell accumulation and oxidative stress overload in the fatty streak lesion were suppressed in mice that received MCI-186 treatment.

Conclusions: MCI-186 administration suppressed the development of atherosclerosis, associated with reduced expression of both immune-activated cells and oxidative stress in fatty streak plaques.

MeSH terms

  • Animals
  • Antipyrine / administration & dosage
  • Antipyrine / analogs & derivatives*
  • Apolipoproteins E / deficiency*
  • Atherosclerosis / drug therapy*
  • Atherosclerosis / genetics
  • Atherosclerosis / immunology
  • Atherosclerosis / pathology
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / pathology
  • Edaravone
  • Free Radical Scavengers / administration & dosage*
  • Mice
  • Mice, Knockout
  • Oxidative Stress / drug effects*
  • Oxidative Stress / genetics
  • Oxidative Stress / immunology
  • Time Factors


  • Apolipoproteins E
  • Free Radical Scavengers
  • Edaravone
  • Antipyrine