Long-lasting results with hydroxylapatite (Radiesse) facial filler

Plast Reconstr Surg. 2006 Sep;118(3 Suppl):15S-21S. doi: 10.1097/01.prs.0000234902.61284.c9.


Background: This study examined the patient satisfaction and longevity of Radiesse, a calcium hydroxylapatite compound, as a facial soft-tissue filler for the glabellar lines, the lips, the nose, the face, and the infraorbital region.

Methods: Radiesse, 0.5 to 2.0 ml, was injected into the designated area in each of the 40 Argentinian male and female patients in the study, using a fine needle. The age range of the patients was 25 to 60 years.

Results: Patients were observed over a period of 18 months. No systemic effects, no immunologic responses, and minimal adverse events (ecchymosis and hematoma in 5 percent of the subjects) occurred with the treatment. In the patient satisfaction survey, 87 percent of the patients rated their level of satisfaction as acceptable or better.

Conclusions: Radiesse was shown to be a highly effective, long-lasting material for facial soft-tissue augmentation. The safe and well-tolerated compound drew high marks in patient satisfaction. A precise injection technique helped minimize potential effects such as nodule formation and helped avoid persistent overcorrection, livid coloring, and asymmetry. Radiesse can be considered a very good option for an aesthetic soft-tissue facial filler when real volumetric augmentation is needed.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biocompatible Materials / administration & dosage
  • Biocompatible Materials / adverse effects
  • Biocompatible Materials / therapeutic use*
  • Cosmetic Techniques* / adverse effects
  • Durapatite / administration & dosage
  • Durapatite / adverse effects
  • Durapatite / therapeutic use*
  • Face
  • Female
  • Humans
  • Injections, Subcutaneous
  • Male
  • Microspheres
  • Middle Aged
  • Patient Satisfaction
  • Rejuvenation
  • Skin Aging*
  • Treatment Outcome


  • Biocompatible Materials
  • Durapatite