Case report. Granular cell tumors of extremities: comparison of benign and malignant variants

Clin Orthop Relat Res. 2007 Feb:455:267-73. doi: 10.1097/01.blo.0000238786.06231.17.


Granular cell tumors are uncommon soft tissue neoplasms that arise from cells of neural origin. We present three patients with this rare tumor: one with a benign tumor, one with a malignant tumor, and one with a histologically benign tumor that later metastasized to the lung. We studied the difficulty in differentiating between the benign and malignant variants using only histology. We also compared the clinical, radiographic, and pathologic features and the criteria for malignancy, natural history, and prognosis.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Adult
  • Arm
  • Buttocks
  • Fatal Outcome
  • Female
  • Granular Cell Tumor / diagnosis
  • Granular Cell Tumor / metabolism
  • Granular Cell Tumor / pathology*
  • Humans
  • Immunohistochemistry
  • Magnetic Resonance Imaging
  • Middle Aged