Retrograde transport from endosomes to the trans-Golgi network

Nat Rev Mol Cell Biol. 2006 Aug;7(8):568-79. doi: 10.1038/nrm1985.


A subset of intracellular transmembrane proteins such as acid-hydrolase receptors, processing peptidases and SNAREs, as well as extracellular protein toxins such as Shiga toxin and ricin, undergoes 'retrograde' transport from endosomes to the trans-Golgi network. Here, we discuss recent studies that have begun to unravel the molecular machinery that is involved in this process. We also propose a central role for a 'tubular endosomal network' in sorting to recycling pathways that lead not only to the trans-Golgi network but also to different plasma-membrane domains and to specialized storage vesicles.

Publication types

  • Review

MeSH terms

  • Animals
  • Endosomes / metabolism*
  • Endosomes / ultrastructure
  • Golgi Apparatus / metabolism*
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Models, Molecular
  • Protein Conformation
  • Protein Transport*
  • trans-Golgi Network / metabolism*


  • Membrane Proteins