Regulation of cardiac hypertrophy by intracellular signalling pathways

Nat Rev Mol Cell Biol. 2006 Aug;7(8):589-600. doi: 10.1038/nrm1983.


The mammalian heart is a dynamic organ that can grow and change to accommodate alterations in its workload. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes. Recent findings in genetically modified animal models implicate important intermediate signal-transduction pathways in the coordination of heart growth following physiological and pathological stimulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcineurin / metabolism
  • Cardiomegaly* / metabolism
  • Cardiomegaly* / pathology
  • Cell Enlargement
  • Cell Membrane / metabolism
  • Humans
  • Mitogen-Activated Protein Kinases / metabolism
  • Myocytes, Cardiac / cytology
  • Myocytes, Cardiac / metabolism
  • NFATC Transcription Factors / metabolism
  • Phenotype
  • Phosphatidylinositol 3-Kinases / metabolism
  • Proto-Oncogene Proteins c-akt / metabolism
  • Signal Transduction / physiology*
  • Transcription Factors / metabolism


  • NFATC Transcription Factors
  • Transcription Factors
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt
  • Mitogen-Activated Protein Kinases
  • Calcineurin