Regulation of cellular senescence by Rb2/p130

Oncogene. 2006 Aug 28;25(38):5257-62. doi: 10.1038/sj.onc.1209613.

Abstract

Growth regulatory functions of Rb2/p130, which aim at a sustained arrest such as in quiescent or differentiated cells, qualify the protein also to act as a central regulator of growth arrest in cellular senescence. In this respect, Rb2/p130 functions are connected to signaling pathways induced by p53, which is a master regulator in cellular senescence. Here, we summarize the pathways, which specify pRb2/p130 to control this arrest program and distinguish its functions from those of pRb/p105.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cellular Senescence / physiology*
  • Humans
  • Precancerous Conditions / pathology
  • Retinoblastoma Protein / physiology*
  • Retinoblastoma-Like Protein p130 / physiology*
  • Signal Transduction / physiology
  • Tumor Suppressor Protein p53 / physiology

Substances

  • Retinoblastoma Protein
  • Retinoblastoma-Like Protein p130
  • Tumor Suppressor Protein p53