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, 50 (9), 3160-1

Escape of Candida From Caspofungin Inhibition at Concentrations Above the MIC (Paradoxical Effect) Accomplished by Increased Cell Wall Chitin; Evidence for beta-1,6-glucan Synthesis Inhibition by Caspofungin

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Escape of Candida From Caspofungin Inhibition at Concentrations Above the MIC (Paradoxical Effect) Accomplished by Increased Cell Wall Chitin; Evidence for beta-1,6-glucan Synthesis Inhibition by Caspofungin

David A Stevens et al. Antimicrob Agents Chemother.

Abstract

Concentrations above the MIC of caspofungin allow growth of some Candida isolates. A strain demonstrating paradoxical growth was grown in the presence and absence of caspofungin, and the cell wall content was analyzed. Beta-1,3-glucan declined 81% in the presence of caspofungin, as expected. Beta-1,6-glucan declined 73%. Chitin increased 898%, demonstrating a mechanism for paradoxical growth-a rapid shift in the key polymer.

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