Abstract
The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antiviral Agents / blood
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Antiviral Agents / pharmacokinetics*
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Esterases / blood*
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Esterases / metabolism
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Female
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Humans
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Male
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Organophosphates / blood
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Organophosphates / pharmacokinetics
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Oseltamivir / blood
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Oseltamivir / pharmacokinetics*
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Prodrugs / pharmacokinetics*
Substances
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Antiviral Agents
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Organophosphates
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Prodrugs
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Oseltamivir
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Esterases