Hepatosplenic gammadelta T-cell lymphoma with ring chromosome 7, an isochromosome 7q equivalent clonal chromosomal aberration

Virchows Arch. 2006 Oct;449(4):479-83. doi: 10.1007/s00428-006-0267-5. Epub 2006 Aug 29.


Hepatosplenic T-cell lymphoma is a rare, clinically aggressive lymphoma. Most cases represent a neoplasm of mature non-activated gammadelta T cells. Isochromosome 7q i(7)(q10) is thought to be the primary cytogenetic abnormality of this disease. In this paper, we describe a hepatosplenic gammadelta T-cell lymphoma case, with clonal ring chromosome 7 exemplifying an isochromosome 7q equivalent clonal aberration. A 62-year-old female patient presented with thrombocytopenia, isolated hepatosplenomegaly, and extremely high levels of LDH. Bone marrow work-up demonstrated a sinusoidal cytotoxic T-cell infiltrate with blastic features, while molecular studies verified monoclonal rearrangement for both TCR gamma and TCR delta genes. Cytogenetics revealed clonal abnormalities including ring chromosome 7, trisomy 8, and der(19), while FISH analysis detected 7q amplification with partial deletion of 7p in ring chromosome 7. To the best of our knowledge, this is the first reported T-cell lymphoma case with ring chromosome 7.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Marrow / chemistry
  • Bone Marrow / pathology
  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 7*
  • Clone Cells
  • DNA, Neoplasm / analysis
  • Fatal Outcome
  • Female
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor*
  • Humans
  • Immunophenotyping
  • In Situ Hybridization, Fluorescence
  • Liver Neoplasms / chemistry
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / genetics
  • Liver Neoplasms / pathology*
  • Lymphoma, T-Cell / chemistry
  • Lymphoma, T-Cell / drug therapy
  • Lymphoma, T-Cell / genetics
  • Lymphoma, T-Cell / pathology*
  • Middle Aged
  • Polymerase Chain Reaction
  • Spectral Karyotyping
  • Splenic Neoplasms / chemistry
  • Splenic Neoplasms / drug therapy
  • Splenic Neoplasms / genetics
  • Splenic Neoplasms / pathology*


  • DNA, Neoplasm