Abstract
Two chromium(III) complexes of glucosaminic acid were synthesized by neutralization and exchange reaction. The formation of 1 : 1 and 2 : 3 (Cr : glucosaminate) complexes was confirmed by elemental analyses and spectroscopic studies. The effect of the complexes on decreasing blood sugar was investigated on type-2 diabetes model rats induced by tetraoxypyrimidine. The results indicated that the effect on decreasing blood sugar was comparable to that of picolinate chromium complex (Cr(pic)(3)) currently used world wide.
MeSH terms
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Alloxan / toxicity
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Animals
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Blood Glucose / metabolism*
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Chromium Compounds / chemical synthesis
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Chromium Compounds / chemistry
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Chromium Compounds / pharmacology*
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Diabetes Mellitus, Experimental / blood
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Diabetes Mellitus, Experimental / chemically induced
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Diabetes Mellitus, Experimental / drug therapy
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Disease Models, Animal
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Glucosamine / analogs & derivatives*
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Glucosamine / chemical synthesis
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Glucosamine / chemistry
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Glucosamine / pharmacology
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Male
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Picolinic Acids / chemical synthesis
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Picolinic Acids / chemistry
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Picolinic Acids / pharmacology
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Rats
Substances
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Blood Glucose
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Chromium Compounds
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Picolinic Acids
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glucosaminic acid
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Alloxan
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Glucosamine