Popular sweetner sucralose as a migraine trigger

Headache. 2006 Sep;46(8):1303-4. doi: 10.1111/j.1526-4610.2006.00543_1.x.


Sucralose (trichlorogalactosucrose, or better known as Splenda) is an artificial sweetener from native sucrose that was approved by the FDA on April 1, 1998 (April Fool's Day). This observation of a potential causal relationship between sucralose and migraines may be important for physicians to remember this can be a possible trigger during dietary history taking. Identifying further triggers for migraine headaches, in this case sucralose, may help alleviate some of the cost burden (through expensive medical therapy or missed work opportunity) as well as provide relief to migraineurs.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Male
  • Middle Aged
  • Migraine Disorders / chemically induced*
  • Sucrose / adverse effects
  • Sucrose / analogs & derivatives*
  • Sweetening Agents / adverse effects*


  • Sweetening Agents
  • Sucrose
  • trichlorosucrose