A method was developed and validated for the simultaneous determination of Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE), BADGE-H2O, BADGE-2H2O, BADGE-H2O-HCl, BADGE-HCl, and BADGE-2HCl in canned food using reversed phase high-performance liquid chromatography (HPLC) with fluorescence detection; chromatographic separation of all seven analytes was achieved (Rs > or = 1.08) using HPLC gradient elution technique. Acetonitrile was used to extract the analytes from the food matrix before subjecting the samples to liquid-liquid extraction, solid-phase extraction for further clean-up and preconcentration prior to HPLC analysis. Excellent inter-day precision data (n = 10) and intra-day precision data (n = 5) were obtained on a 200 microg/kg spiked sample. The RSD ranged from 0.20% to 2.96% for the inter-day precision tests, and 0.04% to 2.82% for the intra-day precision tests. Accuracy was measured at three concentration levels: 200, 1000, and 2000 microg/kg; recoveries ranged from 86.07% to 114.06%. The excellent validation data suggests that this method can be applied on canned foods for the determination of migration of BPA, BADGE and its derivatives from can coatings into food.