The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis

Endocrinology. 2007 Mar;148(3):932-5. doi: 10.1210/en.2006-0926. Epub 2006 Aug 31.


The American Cancer Society estimates 30,180 new cases of thyroid cancer in the United States in 2006. Of all thyroid cancers, 15-20% are follicular thyroid carcinoma (FTC), making this the second most common thyroid malignancy (after papillary carcinoma). A proportion of FTC has been found to be associated with a chromosomal translocation, t (2, 3)(q13;p25), which fuses the thyroid-specific transcription factor paired box-8 with the peroxisome proliferator-activated receptor-gamma nuclear receptor, a ubiquitously expressed transcription factor. This fusion event causes expression of a paired box-8/peroxisome proliferator-activated receptor-gamma fusion protein (PPFP). PPFP is detected in approximately 30% of FTC. In this report we review data on the role of PPFP in FTC, its mechanism of oncogenesis, and PPFP targeting as a strategy in thyroid cancer treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma, Papillary, Follicular / etiology*
  • Carcinoma, Papillary, Follicular / genetics
  • Carcinoma, Papillary, Follicular / therapy
  • Humans
  • Models, Biological
  • Oncogene Proteins, Fusion / physiology*
  • PAX8 Transcription Factor
  • PPAR gamma / genetics
  • PPAR gamma / physiology*
  • Paired Box Transcription Factors / genetics
  • Paired Box Transcription Factors / physiology*
  • Thyroid Neoplasms / etiology*
  • Thyroid Neoplasms / genetics
  • Thyroid Neoplasms / therapy


  • Oncogene Proteins, Fusion
  • PAX8 Transcription Factor
  • PAX8 protein, human
  • PPAR gamma
  • Paired Box Transcription Factors