Growing teratoma syndrome after ovarian germ cell tumors

Obstet Gynecol. 2006 Sep;108(3 Pt 1):509-14. doi: 10.1097/01.AOG.0000231686.94924.41.

Abstract

Objective: To analyze a series of occurrences of growing teratoma syndrome after ovarian germ cell tumors.

Methods: We analyzed a database containing 103 patients affected by pure or mixed ovarian immature teratoma.

Results: We report 12 patients fulfilling growing teratoma syndrome criteria (incidence 12%). The median interval between the diagnosis of ovarian immature teratoma and growing teratoma syndrome was 9 months (range 4-55). Growing teratoma syndrome was revealed by radiological examinations in nine cases (75%). In all cases but one, growing teratoma syndrome occurred in the site involved by the primary tumor. The peritoneum was the first site involved (10 cases, 83%). A complete surgical resection of the growing teratoma syndrome was done in eight cases. The median follow-up was 144 months. Four patients presented a late growing teratoma syndrome recurrence after treatment (second event), more than 5 years after the initial diagnosis, and 14 years later for one patient. All patients but one (lost to follow-up) were still alive at the end of the study.

Conclusion: The treatment of growing teratoma syndrome consists of the surgical resection of the tumor, as completely as possible. Because of the possibility of very late recurrence of growing teratoma syndrome, a prolonged follow-up of patients treated for ovarian immature teratoma is mandatory.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Female
  • Humans
  • Incidence
  • Neoplasm Recurrence, Local / epidemiology
  • Neoplasms, Germ Cell and Embryonal / diagnosis
  • Neoplasms, Germ Cell and Embryonal / epidemiology
  • Neoplasms, Germ Cell and Embryonal / pathology*
  • Neoplasms, Germ Cell and Embryonal / surgery
  • Neoplasms, Second Primary / diagnosis
  • Neoplasms, Second Primary / epidemiology
  • Neoplasms, Second Primary / surgery
  • Ovarian Neoplasms / diagnosis
  • Ovarian Neoplasms / epidemiology
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / surgery
  • Retrospective Studies
  • Survival Rate
  • Syndrome
  • Teratoma / diagnosis
  • Teratoma / epidemiology
  • Teratoma / secondary*
  • Teratoma / surgery
  • Time Factors
  • Treatment Outcome