Abstract
A new sesquiterpene-lactone (nubenolide) belonging to the guaianolide class along with its acetate (nubenolide acetate) and a dimer (bisnubenolide) have been isolated from Salvia nubicola collected from Quetta, Pakistan. Structures of all three new metabolites were elucidated with the aid of spectroscopic techniques including 2D-NMR. However, the structure of nubenolide was finally confirmed via single-crystal X-ray diffraction method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cycloheptanes / chemistry*
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Cycloheptanes / classification
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Cycloheptanes / isolation & purification
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Lactones / chemistry*
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Lactones / isolation & purification
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Magnetic Resonance Spectroscopy / methods
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Models, Molecular
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Molecular Conformation
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Salvia / chemistry*
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Sensitivity and Specificity
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes, Guaiane / chemistry*
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Sesquiterpenes, Guaiane / classification
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Sesquiterpenes, Guaiane / isolation & purification
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Species Specificity
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Stereoisomerism
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X-Ray Diffraction
Substances
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Cycloheptanes
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Lactones
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Sesquiterpenes
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Sesquiterpenes, Guaiane
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bisnubenolide
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guaiane
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nubenolide