Exploring the potential of N-methyl pyrrolidone as a cosurfactant in the microemulsion systems

Y G Bachhav; A A Date; V B Patravale

doi:10.1016/j.ijpharm.2006.07.014

Exploring the potential of N-methyl pyrrolidone as a cosurfactant in the microemulsion systems

Int J Pharm. 2006 Dec 1;326(1-2):186-9. doi: 10.1016/j.ijpharm.2006.07.014. Epub 2006 Jul 15.

Authors

Y G Bachhav¹, A A Date, V B Patravale

Affiliation

¹ Department of Pharmaceutical Sciences and Technology, University Institute of Chemical Technology, Matunga, Mumbai 400019, India.

PMID: 16949777
DOI: 10.1016/j.ijpharm.2006.07.014

Abstract

The effect of N-methyl pyrrolidone (NMP) on the phase behavior of two ternary systems, viz. PEG-35-castor oil (CremophoreEL)-glyceryl caprylate/caprate (Capmul MCM)-water and PEG-35-castor oil (CremophoreEL)-isopropyl myristate-water was studied. The study indicated that NMP has considerable influence on the phase behavior of both the systems. NMP increased the area of microemulsion formation in both the systems. Moreover, it also led to reduction/disappearance in the gelling region of the CremophoreEL-isopropyl myristate-water system. These observations allowed us to conclude that NMP can be considered as a cosurfactant for the development of biocompatible microemulsions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chemistry, Pharmaceutical / methods
Drug Compounding
Emulsions
Gels
Kinetics
Polyethylene Glycols / chemistry*
Pyrrolidinones / chemistry*
Solubility
Surface-Active Agents / chemistry*
Technology, Pharmaceutical / methods
Water / chemistry

Substances

Emulsions
Gels
Pyrrolidinones
Surface-Active Agents
Water
Polyethylene Glycols
N-methylpyrrolidone