Chapter 28: Studies to assess the long-term efficacy and effectiveness of HPV vaccination in developed and developing countries

Vaccine. 2006 Aug 31;24 Suppl 3:S3/233-41. doi: 10.1016/j.vaccine.2006.05.109.


We review studies of the implementation of human papillomavirus (HPV) vaccination programmes in developed and developing countries. The review spans the period from establishment of long-term vaccine efficacy follow-up studies, operational research on issues of vaccine preparedness, and relevant predictive modelling studies during the pre-licensure phase to plans of phase IV effectiveness trials, forms of epidemiological surveillance, and further operational research in the post-licensure phase. Much of the research is already ongoing. Depending on the results of the planned immuno bridging studies among HIV-negative and HIV-positive women, further phase III and/or phase IV trials may be warranted.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Developed Countries
  • Developing Countries
  • Humans
  • Papillomavirus Infections / prevention & control*
  • Papillomavirus Vaccines / immunology*
  • Product Surveillance, Postmarketing*
  • Research / trends


  • Papillomavirus Vaccines