Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases

Vaccine. 2006 Aug 31;24 Suppl 3:S3/26-34. doi: 10.1016/j.vaccine.2006.05.026. Epub 2006 Jun 2.


Geographical widespread data on human papillomavirus (HPV) type-distribution are essential for estimating the impact of HPV-16/18 vaccines on cervical cancer and cervical screening programmes. Epidemiological studies employing a variety of HPV typing protocols have been collated in meta-analyses. HPV-16/18 is estimated to account for 70% of all cervical cancers worldwide, although the estimated HPV-16/18 fraction is slightly higher in more developed (72-77%) than in less developed (65-72%) regions. About 41-67% of high-grade squamous intraepithelial lesion (HSIL), 16-32% of low-grade squamous intraepithelial lesion (LSIL) and 6-27% of atypical squamous cells of undetermined significance (ASCUS) are also estimated to be HPV-16/18-positive, thus highlighting the increasing relative frequency of HPV-16/18 with increasing lesion severity. After HPV-16/18, the six most common HPV types are the same in all world regions, namely 31, 33, 35, 45, 52 and 58; these account for an additional 20% of cervical cancers worldwide.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Molecular Epidemiology*
  • Neoplasms / epidemiology
  • Neoplasms / virology*
  • Papillomaviridae / classification*
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / complications
  • Papillomavirus Infections / epidemiology
  • Papillomavirus Infections / virology*
  • Prevalence