Prolonged electroencephalogram monitoring for seizures and their treatment

Clin Perinatol. 2006 Sep;33(3):649-65, vi. doi: 10.1016/j.clp.2006.06.004.


This article reviews the diagnosis of neonatal seizures using routine electroencephalogram (EEG) examinations and long-term EEG monitoring. EEG is considered the gold standard for identifying the presence and quantifying the burden of neonatal seizures. The most common medication used to treat neonatal seizures is phenobarbital, although its efficacy has never been demonstrated by a formal, randomized, placebo-controlled drug trial.

Publication types

  • Review

MeSH terms

  • Anticonvulsants / therapeutic use
  • Electroencephalography / classification
  • Electroencephalography / drug effects
  • Electroencephalography / methods*
  • Humans
  • Infant, Newborn
  • Monitoring, Physiologic / methods*
  • Phenobarbital / therapeutic use
  • Seizures / diagnosis*
  • Seizures / drug therapy
  • Signal Processing, Computer-Assisted


  • Anticonvulsants
  • Phenobarbital