Fatty Acid Synthesis and Elongation in Yeast

Biochim Biophys Acta. 2007 Mar;1771(3):255-70. doi: 10.1016/j.bbalip.2006.07.004. Epub 2006 Jul 21.

Abstract

Fatty acids are essential compounds in the cell. Since the yeast Saccharomyces cerevisiae does not feed typically on fatty acids, cellular function and growth relies on endogenous synthesis. Since all cellular organelles are involved in--or dependent on--fatty acid synthesis, multiple levels of control may exist to ensure proper fatty acid composition and homeostasis. In this review, we summarize what is currently known about enzymes involved in cellular fatty acid synthesis and elongation, and discuss potential links between fatty acid metabolism, physiology and cellular regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetyl-CoA Carboxylase / metabolism
  • Coenzymes / metabolism
  • Cytosol / metabolism
  • Endoplasmic Reticulum / metabolism
  • Fatty Acid Synthases / metabolism
  • Fatty Acids / biosynthesis*
  • Mitochondria / enzymology
  • Mitochondria / metabolism
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism

Substances

  • Coenzymes
  • Fatty Acids
  • Saccharomyces cerevisiae Proteins
  • Fatty Acid Synthases
  • Acetyl-CoA Carboxylase